It is possible that his presence will be D2R Items perceived through these intermediaries unless circumstances make him a victim. Tyrael is still feeling the effects of the destruction of his Worldstone at the conclusion in Diablo 2. The mystical artifact shielded Sanctuary from Heaven and Hell and now is the protector of the land on its behalf. Tyrael is unlikely to lead any further expeditions into Hell or even go further beyond his current position at the Pandemonium Fortress, where he might offer advice similar to Deckard Cain to those who are willing to listen.
Five Diablo playable classes have been revealed so far and all of them are variations on the options offered in previous games. Since each game has introduced something new and exciting, maybe Tyrael could become an active participant in the fight and help balance the sides by giving players the option to acquire angelic or demon powers , in exchange for responsibilities to Sanctuary. This kind of system could be a natural progression from the multi-tree development that was made public for the series.
It is unlikely that Blizzard intends to turn Angels as well as Demons into classes, since the game's focus is on those who are caught between the two. As a mortal trapped between Heaven and Hell Tyrael is in an unimaginable position in the entire Diablo legends. He is more likely to be an equalizer in the tale, perhaps even an impartial voice, instead of taking sides like previously. Even when he is forced to take the side of his opponent, Tyrael has come to understand the value of mortals, which is the way he is likely to be a part of the events of D2R Ladder Items Buy.