The wearing of face masks will no longer be legally required in Welsh health and social care services from Monday.
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First Minister Mark Drakeford is set to axe the last of Wales' Covid rules, which have been in place in some form since March 2020.
Ministers said the public health situation had continued to improve over the last few weeks.
Wales was the last part of the UK with Covid restrictions still in place.
However most of the rules that impacted people's day to day lives, such as wearing face masks in shops and on public transport and self-isolation rules, ended in March.
Numbers testing positive for Covid have fallen in recent weeks, with the number of hospital patients testing positive for the virus also declining, according to recent estimates.
However the Welsh government said the NHS continued to experience "emergency and pandemic pressures".
Guidance will remain in place strongly recommending the use of face coverings in health settings to help protect the most vulnerable.